Chemical Screening Made Better Through Transform Tox Testing Challenge

Numerous discoveries in the field of health and sciences have been made through the years. Each of these discoveries contributed to the betterment of the world and the people living in it. However, these discoveries are not 100 percent perfect just like their makers, and this is why the experts are continuously searching for ways to further improve the existing methods and discoveries, and make them better for the benefit of the modern generation, and the future generations to come. With this thought in mind, some of the concerned agencies come with a challenge that can help them make it possible to render remarkable and breakthrough changes that can bring advantages to the present and future generations.

The United States Environmental Protection Agency, the NIH’s National Toxicology Program in the National Institute of Environmental Health Sciences, and the National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS) launched the Transform Tox Testing Challenge which aimed to award as much as $1 million for the sake of improving the predictivity and relevance of the data being generated from the automated chemical screening technology which is being used for the purpose of testing toxicity.

Out of all those chemicals that are available and used these days, only a few of these were really completely evaluated for their possible health effects. The scientist from the agencies mentioned above are using HTS or high throughput screening for the evaluation of the possible effects on health of all those numerous chemicals being used today. This high throughput screening makes use of automated methods which allow for a bigger quantity of chemicals to be quickly evaluated for a certain kind of biological activity.

The existing HTS assays don’t totally incorporate the chemical metabolism and this is why they might miss those chemicals which can end up metabolized into a form that is more toxic once it gets inside the body. The Transform Tox Testing Challenge: Innovating for Metabolism has invited all the innovative thinkers to look for brand new ways for the incorporation of the physiological levels of the chemical metabolism to the HTS assays. It is expected to give researchers a hand in a more accurate assessment of the effects of different chemicals and offer better protection to human health.

The teams who joined the challenge competed in three stages to bag an award worth $1 million. In the first stage, the teams were asked to submit practical designs that can be fully implemented. Around 10 submissions were bound to bring home a prize of $10,000 each together with the invitation of continuing on to the second stage.

In the second stage, a prototype should be made to show the suggested idea in full action. Around 5 participants can receive as much as $100,000 each together with the invitation to continue on to the last stage. The last stage required a commercial viable technology or method that the EPA and its partners will test and demonstrate. As the result of this test, one participant gets to bring home as much as $400,000 for being able to come up with a device or method which will pave way for the creation of technologies to offer metabolic competence to the HTS assays.

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